Bile acids in metabolic dysfunction-associated steatotic liver disease
Enver Zerem, Suad Kunosic, Admir Kurtcehajic, Dina Zerem, Omar Zerem
World Journal of Hepatology, August 27, 2025
Bile acids are no longer just “digestive helpers” – they govern key metabolic processes and are becoming central to understanding MASLD and MASH. Discover how new therapeutic strategies are changing the approach to fatty liver disease.
Bile acids are not only key players in lipid digestion and cholesterol homeostasis but also act as potent signaling molecules. By activating receptors such as FXR and TGR5, they regulate diverse metabolic pathways, extending their role far beyond classical digestion. These insights place BAs and their receptors at the center of research on metabolic dysfunction–associated steatotic liver disease (MASLD) and steatohepatitis (MASH). This article highlights their role in hepatic lipid regulation and emerging therapeutic strategies.
DOI: https://dx.doi.org/10.4254/wjh.v17.i8.108606
Citation: Zerem E, Kunosic S, Kurtcehajic A, Zerem D, Zerem O. Bile acids in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2025; 17(8): 108606